Training in fruit-fly genetics
Muller studied at Columbia and participated in the fruit-fly research surrounding Morgan. He investigated linked genes, genetic markers and methods for measuring mutation, continuing experiments at Rice and the University of Texas.
References: [1]
X-rays and inherited changes
In late 1926 Muller obtained evidence that X-rays could produce numerous gene mutations and chromosomal changes, publishing the results in 1927. The work supplied a more systematic experimental route to genetic variation and linked radiation’s biological effects with genetics. His 1946 Nobel Prize recognized X-ray-induced mutation.
An international career
Muller worked in Germany and the Soviet Union before leaving as Lysenko’s anti-genetics movement grew. He continued research in Edinburgh and the United States, joining Indiana University in 1945 and investigating mutation, radiation and genetic change.
References: [1]